NFL Week 1 Betting Odds: Updated Point Spreads & O/Us

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Week 1 of the 2021-22 NFL regular season is set to kick off on Thursday night with a primetime clash between the defending Super Bowl champion Tampa Bay Buccaneers and America’s Team, the Dallas Cowboys.

Ahead of the start of the season, the oddsmakers shared their updated betting odds — including point spreads and over/unders — for every game on the schedule.

The Los Angeles Rams, San Francisco 49ers, and Buccaneers are the biggest favorites of the week at -7.5, while the closest game to call is a pick ’em between the Los Angeles Chargers and Washington Football Team.

Who is favored to bring home the wins in Week 1 and watch action can you get in on?

A full look at the updated Week 1 betting odds can be seen below, via BetOnline.com.


NFL Week 1 Betting Odds

Dallas Cowboys vs Tampa Bay Buccaneers (-7½)

Over/Under                                           52

Note: The game opened with Tampa Bay -6. The total is unchanged.

Pittsburgh Steelers vs Buffalo Bills (-6½)       

Over/Under                                           48

Note: The game opened with Buffalo -6. The total went down 3½ points.

New York Jets vs Carolina Panthers (-5)         

Over/Under                                           45

Note: The game opened with Carolina -4. The total has went up two points.

Jacksonville Jaguars (-1½) vs Houston Texans

Over/Under                                           44½

Note: The game opened with Jacksonville -1½. The total went down one point.

Arizona Cardinals vs Tennessee Titans (-3)    

Over/Under                                           52

Note: The game opened with Tennessee -2. The total went up one point.

Los Angeles Chargers (pk) vs Washington Football Team (pk)                      

Over/Under                                           44½

Note: The game opened with Los Angeles -1. The total went down one point.

Philadelphia Eagles vs Atlanta Falcons (-3½) 

Over/Under                                           46

Note: The line is unchanged. The total went up 2½ points.

Seattle Seahawks (-2½) vs Indianapolis Colts

Over/Under                                           48½

Note: The game opened with Indianapolis -2½. The total went down four points.

Minnesota Vikings (-3) vs Cincinnati Bengals 

Over/Under                                           48

Note: The line is unchanged. The total went down one point

San Francisco 49ers (-7½) vs Detroit Lions

Over/Under                                           45½

Note: The line is unchanged. The total went down ½ point.

Denver Broncos (-2½) vs New York Giants                             

Over/Under                                           42

Note: The game opened with Denver -1. The total went down ½ point.

Green Bay Packers (-4½) vs New Orleans Saints

Over/Under                                           50½

Note: The game opened with New Orleans -3. The total went up ½ point.

Cleveland Browns vs Kansas City Chiefs (-6½)          

Over/Under                                           53

Note: The game opened with Kansas City -5½. The total went up 1½ points

Miami Dolphins vs New England Patriots (-3) 

Over/Under                                           43½

Note: The game opened with New England -1½. The total went down three points

Chicago Bears vs Los Angeles Rams (-7½)    

Over/Under                                           44

Note: The game opened with Los Angles -7. The total went down two points.

Baltimore Ravens (-4½) vs Las Vegas Raiders            

Over/Under                                           51

Note: The game opened with Baltimore -6½. The total is unchanged.

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