NFL Betting Odds 2022: Week 6 Opening Lines & Over/Unders

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The 2022 NFL regular season is in full swing and the start of another week is just around the corner. While there is still one game remaining in Week 5 with the Las Vegas Raiders set to face the Kansas City Chiefs on Monday Night Football, but it’s never too early to look ahead.

With Week 6 just a few days away, the oddsmakers released the opening lines and over/unders for the upcoming week.

According to the odds, the Los Angeles Rams will enter Week 6 as the biggest favorites on the board at -9 over the Carolina Panthers. The highest-scoring game is projected to be the Buffalo Bills vs. Kansas City Chiefs with the over/under set for 53 total points.

Who are all of the favorites in Week 6?

A full look at the opening lines and betting odds can be seen below, via BetOnline.ag.


NFL Week 6 Opening Lines & Betting Odds

NEW YORK, USA - MAY 28, 2018: Rows of american football balls in NFL Experience in Times Square, New York, a first-of-its-kind live action attraction, combining interactive games and 4D theatre.

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Thursday, Oct 13, 2022 

  • Washington Commanders at Chicago Bears (-1) | Over/Under: 40

Sunday, Oct 16, 2022

  • Tampa Bay Buccaneers (-7½) at Pittsburgh Steelers | Over/Under: 43
  • Cincinnati Bengals (-1½) at New Orleans Saints | Over/Under: 44
  • New England Patriots at Cleveland Browns (-2½) | Over/Under: 42½
  • New York Jets at Green Bay Packers (-7) | Over/Under: 44½
  • Jacksonville at Indianapolis Colts (-1½) | Over/Under: 41
  • Baltimore Ravens (-6) at New York Giants | Over/Under: 44
  • Minnesota Vikings at Miami Dolphins (-1½) | Over/Under: 46½
  • San Francisco 49ers (-6) at Atlanta Falcons | Over/Under: 42½
  • Carolina Panthers at Los Angeles Rams (-9) | Over/Under: 41½
  • Arizona Cardinals (-2½) at Seattle Seahawks | Over/Under: 51½
  • Buffalo Bills (-1½) at Kansas City Chiefs | Over/Under: 53
  • Dallas Cowboys at Philadelphia Eagles (-5½) | Over/Under: 43½

Monday, Oct 17, 2022

  • Denver Broncos at Los Angeles Chargers (-4½) | Over/Under: 46½
Colts vs Broncos Live Stream: Watch Thursday Night Football Online
Colts vs Broncos Live Stream: Watch Thursday Night Football Online