NFL Week 16 Opening Lines & Betting Odds: 5 Double-Digit Favorites

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There are still a handful of games remaining on the Week 15 NFL schedule thanks to rescheduling amid coronavirus outbreaks across the league. But that hasn’t stopped people from looking ahead to Week 16 which kicks off on Thursday night with the Tennessee Titans hosting the San Francisco 49ers.

Ahead of the new week, the oddsmakers released the early lines and betting odds for each game on the schedule.

This week, five teams are double-digit favorites with the Tampa Bay Buccaneers as the biggest favorite at -13.5 over the Carolina Panthers. Of course, with the Bucs being shut out on Sunday Night Football and injuries to Mike Evans, Chris Godwin, and Leonard Fournette, we could see a big change to the line.

Other double-digit favorites include the Los Angeles Chargers, Dallas Cowboys, Kansas City Chiefs, and Philadelphia Eagles.

Who are all of the favorites in Week 16?

A full look at the opening lines and betting odds can be seen below, via BetOnline.ag.


Week 16 Opening Lines

Thursday, December 23

  • San Francisco (-3) at Tennessee | Over/Under: 44½

Saturday, December 25

  • Cleveland at Green Bay (-7½) | Over/Under: 45
  • Indianapolis at Arizona (-1½) | Over/Under: 49

Sunday, December 26

  • Detroit at Atlanta (-4½) | Over/Under: 44
  • Baltimore at Cincinnati (-2½) | Over/Under: 43½
  • Los Angeles Rams (-3) at Minnesota | Over/Under: 49½
  • Buffalo at New England (-1½) | Over/Under: 44½
  • Tampa Bay (-13½) at Carolina | Over/Under: 48½
  • Los Angeles Chargers (-10½) at Houston | Over/Under: 47½
  • Chicago at Seattle (-7½) | Over/Under: 44½
  • Pittsburgh at Kansas City (-10½) | Over/Under: 46½
  • Denver at Las Vegas (-1½) | Over/Under: 42½
  • Washington at Dallas (-10½) | Over/Under: 47

Monday, December 27

  • Miami at New Orleans (-2½) | Over/Under: 40½
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