NFL Betting Odds 2021: Opening Spreads & O/Us For Week 1

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The NFL schedule is being released on Wednesday, May 12, but before the NFL Network could host its primetime schedule release special, each network was allowed to unveil their games for Week 1.

As a result, we already know the full Week 1 schedule and we now know the opening odds — lucky for us gambling degenerates looking to get a headstart on crafting our parlays.

The oddsmakers released the point spreads and over/unders for each and every game on the schedule.

The San Francisco 49ers are the biggest favorites in the opening week, having a 7-point edge over the Detroit Lions. The Denver Broncos and Los Angeles Chargers, meanwhile, are the smallest favorites with a one-point edge over the New York Giants and Washington Football Team respectively.

Will your favorite team be favored in Week 1?

A full look at the opening point spreads and over/unders for Week 1 can be seen below, via BetOnline.ag.

Dallas Cowboys vs Tampa Bay Buccaneers (-6)

  • Over/Under                                           52

Pittsburgh Steelers vs Buffalo Bills (-6)          

  • Over/Under                                           51½

New York Jets vs Carolina Panthers (-4)         

  • Over/Under                                           43

Jacksonville Jaguars (-1½) vs Houston Texans

  • Over/Under                                           45½

Arizona Cardinals vs Tennessee Titans (-2)    

  • Over/Under                                           51

Los Angeles Chargers (-1) vs Washington Football Team                  

  • Over/Under                                           45½

Philadelphia Eagles vs Atlanta Falcons (-3½) 

  • Over/Under                                           46

Seattle Seahawks vs Indianapolis Colts (-2½)

  • Over/Under                                           52½

Minnesota Vikings (-3) vs Cincinnati Bengals 

  • Over/Under                                           49

San Francisco 49ers (-7½) vs Detroit Lions

  • Over/Under                                           45½

Denver Broncos (-1) vs New York Giants                                

  • Over/Under                                           42½

Green Bay Packers vs New Orleans Saints (-3)          

  • Over/Under                                           (off the board)

Cleveland Browns vs Kansas City Chiefs (-5½)          

  • Over/Under                                           51½

Miami Dolphins vs New England Patriots (-1½)          

  • Over/Under                                           46½

Chicago Bears vs Los Angeles Rams (-7)       

  • Over/Under                                           46

Baltimore Ravens (-6½) vs Las Vegas Raiders            

  • Over/Under                                           51
Here’s The Full NFL Week 1 Schedule For The Upcoming Season
Here’s The Full NFL Week 1 Schedule For The Upcoming Season
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