49ers’ Draft Prospects: Key Positions to Watch in 2025

As a fan, you’ve undoubtedly got your eye on the 49ers’ 2025 draft picks, and rightly so, as it promises intrigue for supporters and analysts alike. Focusing on key positions like interior defensive line and edge rushers can greatly impact next season’s strategy – and the 49ers are well aware of this fact. While you’re keeping up with the latest developments in the 49ers lineup, San Francisco’s preferences in a running back could surprise you. 

Then there’s the question of whether they’ll pursue a top-tier tight end or bolster the offensive line. 

Curious about what the 49ers truly have up their sleeves this draft season? The answer might redefine the team’s future trajectory.

Key Takeaways

• Strengthening the offensive line remains a key priority for the 49ers in the 2025 draft,
• Interior defensive line prospects like Mason Graham and Kenneth Grant offer valuable depth options,
• Cornerback options like Travis Hunter and Will Johnson can enhance the 49ers’ secondary strategy,
• Ashton Jeanty and Omarion Hampton are running backs with potential to elevate the backfield,
• Versatile edge defenders like Abdul Carter and Mike Green can boost the 49ers’ defense.

Defensive Line Focus

When examining the 49ers’ draft prospects, it’s crucial to explore the defensive line focus, especially when you get into the interior defensive linemen. The 2025 draft class offers a notably deep edge defender group, providing ample opportunities for teams to strengthen their defenses. This talent influx could impact San Francisco 49ers odds, particularly if they land a high-upside player in the trenches. You’ll find Mason Graham from Michigan at the top of the list. His elite burst and relentless play (overshadowing his shorter arms) makes him an attractive proposition.

There are others in the mix. Kenneth Grant, also from Michigan, combines size and quickness, excelling in one-on-one situations. Walter Nolen from Mississippi offers strength in run defense but requires refinement in technique. Then there’s Oregon‘s Derrick Harmon who boasts NFL-level quickness and a varied pass-rush repertoire, making him an effective 3-technique option.

Finally, there’s Darius Alexander from Toledo, who stands out with NFL-caliber measurables and versatility for odd and even fronts, providing the potential for significant contributions as a starter.

Running Back Options

Although focusing on the running back options for the 49ers may not seem the top priority, it’s vital to contemplate the dynamic talent available in this draft class.

Ashton Jeanty from Boise State dazzles with impressive footwork and balance, making him a first-round offensive weapon. If you favor a physical runner, consider Omarion Hampton from North Carolina, who thrives in zone schemes, offering immediate impact with his explosive size. NFL scouts have noted that strongest positions within the 2025 draft include running back, emphasizing the depth of talent available.

Arizona State’s Cameron Skattebo excels in gap schemes with a tackle-breaking mentality. Quinshon Judkins is a strong north-to-south runner suited for gap-heavy schemes.

Dylan Sampson, a speedster from Tennessee, shows big-play potential and develops into a receiver. Exploring these options guarantees any offensive strategy stays ahead.

Edge Defender Potential

Shifting focus from the backfield to the trenches, the edge defender position offers the 49ers a remarkable opportunity to bolster their pass rush significantly.

Fans should pay special attention to Abdul Carter from Penn State. His speed and versatility, reminiscent of players like Von Miller, make him an easy projected top-five pick.

Mike Green from Marshall also intrigues with his explosive first step. If you’re looking for someone to contribute immediately, James Pearce Jr. could be your guy, bringing improved run defense and clear pass-rush skills.

The 49ers may also be considering Shemar Stewart who brings massive physical presence, though his technique needs work. Mykel Williams is another option. He shows inconsistent dominance, but in a 4-3 system, he could thrive.

These players promise significant defensive upgrades.

Tight End Prospects

The tight end prospects for the 49ers offer four standout candidates that could markedly boost the team’s offensive versatility. With so much attention on upcoming NFL games and props, it’s worth considering how these prospects might soon impact offensive schemes. 

• Colston Loveland, from Michigan, is a first-round prospect known for his elite athleticism, field-stretching ability, and clutch catches. His size and speed make him a mismatch nightmare.
• Tyler Warren, from Penn State, showcases remarkable physicality and versatility, excelling in red-zone situations and multiple formations. With 104 catches for 1,233 yards in 2024, he’s a reliable early Day 2 option.
• Harold Fannin Jr., from Bowling Green, stands out with his reliable hands and blocking skills, making him a solid Day 2 selection.
• Mason Taylor from LSU, projected for Day 2 or 3, offers soft hands and needs minor tweaks in blocking.

Cornerback Considerations

After examining tight end prospects, it’s time to focus on potential assets for the 49ers’ secondary.

With several promising candidates, you should keep an eye on cornerbacks who bring a mix of speed, size, and versatility. Players like Travis Hunter from Colorado, with his elite ball skills, and Will Johnson from Michigan, who boasts exceptional foot quickness, can enhance the 49ers’ secondary strategy.

Here are some considerations:

• Versatility: Jahdae Barron’s ability to play multiple positions including safety and nickel can add depth,
• Physical Attributes: Players like Azareye’h Thomas and Shavon Revel bring a strong physical presence and impressive speed,
• Zone-Scheme Suitability: Cornerbacks like Travis Hunter and Will Johnson are ideal for zone coverage systems.

Scout these features for effective draft decisions.

Offensive Line Needs

As the 49ers plan for the upcoming draft, addressing offensive line needs is vital to strengthen their roster.

The team might do well to focus on offensive tackle prospects like Will Campbell and Kelvin Banks for their versatility, even though Campbell’s best fit might be inside. Athletes like Armand Membou and Josh Simmons are worthy of serious evaluation, though Simmons is bouncing back from an ACL injury.

While the depth at guard is lacking, consider Tyler Booker or Tate Ratledge, known for their pass-blocking skills and power.

At center, prospects like Jared Wilson could be promising with refinement in football IQ.

Building the Blueprint for a Championship Run

The 49ers’ 2025 draft strategy isn’t just about filling gaps—it’s about crafting a sustainable, championship-caliber roster. From defensive powerhouses like Mason Graham and Abdul Carter to offensive difference-makers like Ashton Jeanty and Colston Loveland, each prospect represents a calculated move toward long-term success. 

Whether San Francisco leans into shoring up the trenches or surprises with skill-position talent, the choices made in this draft could redefine their trajectory. As fans, all that’s left is to watch the blank spaces on the blueprint being filled—because what the 49ers build in April could be what carries them deep into January.