March Madness Sweet 16 Odds: Opening Lines & Point Spreads

March 17, 2016 - Spokane, WA: A game ball sits on court the day prior to the start of the 2016 NCAA Men's Basketball Tournament games at the Spokane Veterans Memorial Arena.

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March Madness is onto the Sweet 16 and after a wild opening weekend the 2022 NCAA Tournament’s Road to the Final Four is set to continue later this week.

Ahead of the Sweet 16, the oddsmakers shared their thoughts on how the action could play out.

Predictably, the biggest favorite in the Sweet 16 is No. 3 Purdue over Cinderella No. 15 seed Saint Peter’s, while No. 11 Iowa State vs. No. 10 Michigan and No. 3 Texas Tech vs. No. 2 Duke have the closest lines.

A full look at the opening lines and point spreads for the Sweet 16 of the 2022 NCAA Tournament can be seen below, via Caesars Sportsbook.


March Madness Sweet 16 Betting Odds

No. 4 Arkansas (+280) vs. No. 1 Gonzaga (-360)
Point Spread: Gonzaga -7.5 | O/U: 155.5

No. 8 UNC (+125) vs. No. 4 UCLA (-145)
Point Spread: UCLA -2.5 | O/U: 142.5

No. 4 Providence (+280) vs. No. 1 Kansas (-365)
Point Spread: Kansas -8 | O/U: 141

No. 15 Saint Peter’s (+650) vs. No. 3 Purdue (-1000)
Point Spread: Purdue -12/5 | O/U: TBD

No. 11 Michigan (+175) vs. No. 2 Villanova (-210)
Point Spread: Villanova -4.5 | O/U: 135.5

No. 5 Houston (+116) vs. No. 1 Arizona (-140)
Point Spread: Arizona -2.5 | O/U: 145.5

No. 11 Iowa State vs. No. 10 Michigan
Point Spread: Iowa State -1 | O/U: 133.5

No. 3 Texas Tech (-120) vs. No. 2 Duke (+100)
Point Spread: Texas Tech -1.5 | O/U: 136.5

March Madness Sweet 16: Printable 2022 NCAA Tournament Bracket
March Madness Sweet 16: Printable 2022 NCAA Tournament Bracket
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