NFL Betting Odds 2021: Opening Spreads & O/Us For Week 1

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The NFL schedule is being released on Wednesday, May 12, but before the NFL Network could host its primetime schedule release special, each network was allowed to unveil their games for Week 1.

As a result, we already know the full Week 1 schedule and we now know the opening odds — lucky for us gambling degenerates looking to get a headstart on crafting our parlays.

The oddsmakers released the point spreads and over/unders for each and every game on the schedule.

The San Francisco 49ers are the biggest favorites in the opening week, having a 7-point edge over the Detroit Lions. The Denver Broncos and Los Angeles Chargers, meanwhile, are the smallest favorites with a one-point edge over the New York Giants and Washington Football Team respectively.

Will your favorite team be favored in Week 1?

A full look at the opening point spreads and over/unders for Week 1 can be seen below, via BetOnline.ag.

Dallas Cowboys vs Tampa Bay Buccaneers (-6)

Pittsburgh Steelers vs Buffalo Bills (-6)          

New York Jets vs Carolina Panthers (-4)         

Jacksonville Jaguars (-1½) vs Houston Texans

Arizona Cardinals vs Tennessee Titans (-2)    

Los Angeles Chargers (-1) vs Washington Football Team                  

Philadelphia Eagles vs Atlanta Falcons (-3½) 

Seattle Seahawks vs Indianapolis Colts (-2½)

Minnesota Vikings (-3) vs Cincinnati Bengals 

San Francisco 49ers (-7½) vs Detroit Lions

Denver Broncos (-1) vs New York Giants                                

Green Bay Packers vs New Orleans Saints (-3)          

Cleveland Browns vs Kansas City Chiefs (-5½)          

Miami Dolphins vs New England Patriots (-1½)          

Chicago Bears vs Los Angeles Rams (-7)       

Baltimore Ravens (-6½) vs Las Vegas Raiders            

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